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KMID : 0616120160470020192
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 2 p.192 ~ p.196
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Gas Chromatographic Analysis and Cholinesterase Activity of the Essential Oil from Korean Agastache rugosa
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Choi Jae-sue
Song Byong-Min
Park Hee-Juhn
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Abstract
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The herb of Agastache rugosa (Lamiaceae) called Korean mint as a spice or Agastache Herba as a crude drug is known to contain highly fragrant volatile substances. This research aimed to establish the quantitative gas chromatography (GC) method on the essential oil of A. rugosa using the three standard compounds, estragole, methyleugenol, pulegone, and to find whether the essential oil has anti-Alzheimer’s activity. The GC quantification method was established by determining the linearity of calibration curve (R2), linear range, and both limit-of-detection (LOD) and limit-of-quantification (LOQ). The IC50 of the essential oil on the activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were determined to be 69.06 ±0.26 and 76.71±0.58 mg/ml, respectively.
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KEYWORD
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Agastache rugosa, Lamiaceae, Essential oil, Gas chromatography, Acetylcholinesterase, Butyrylcholinesterase
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